The research team of Liu Dongbo, a professor at Hunan Agricultural University in China, published an article titled “Intermittent Calorie Restriction Diet for Type II Diabetes” on December 14 in the Journal of Clinical Endocrinology & Metabolism. The Impact of Mitigation: A Randomized Controlled Trial’ research paper. Studies have found that 3 months of intermittent fasting (Intermittent Fasting) can make the condition of type 2 diabetic patients remission.
Intermittent fasting is regarded as a safer and easier-to-execute weight loss method, which aims to eat within a limited time, including time-limited eating, alternate-day fasting, all-day fasting, religious fasting, etc. Take the 168 fasting method popular in recent years as an example. You can only eat for 8 hours a day, and you are prohibited from taking calories for the remaining 16 hours.
Liu Dongbo’s team stated that although some studies have investigated the health benefits of intermittent fasting for humans, the efficiency in the context of diabetes remission remains to be elucidated. Studies have found that 3 months of intermittent fasting can enable patients with type II diabetes to gain Remission, and diabetes medication can be discontinued and maintained for at least one year.
The team proposed a randomized controlled clinical study to investigate the efficacy of Chinese Medical Nutrition Therapy (CMNT) for inducing diabetes remission. Diabetes remission, defined as a stable glycated hemoglobin (HbA1c) level of less than 6.5% (48 mmol/mol) after discontinuation of antidiabetic medication for at least 3 months, was assessed as the primary outcome. In addition, an additional 12-month follow-up was performed to confirm stable status.
The study reports that CMNT therapy is a newly proposed method of intermittent fasting that involves fasting for 5 days followed by reintroduction of daily food for 10 days. The CMNT diet includes everyday foods such as wheat, barley, rice, rye, and oats, and is characterized by a reduction in glycemic load, calories, and carbohydrates, and an increase in unsaturated fatty acids.
The team screened and obtained 72 research participants, all of whom had type 2 diabetes for 1 to 11 years, aged between 38 and 72, and whose body mass index (BMI) was between 19 and 30.4 between.
BMI index is one of the weight evaluation methods, the algorithm is weight kilograms/height meter 2 (kg/m2), greater than or equal to 24 is overweight, more than 27 is obese, and more than 30 is moderately obese.
In the experiment, the research subjects were randomly divided into the experimental group and the control group. The experimental group received CMNT therapy, and the control group could eat freely. The experimental group underwent intermittent fasting intervention for 3 months, 15 days as a cycle, a total of 6 cycles, and subjects were required to restrict their diet for 5 days in each cycle. The content of the CMNT therapy diet is about 840 calories per day, including 46% carbohydrates, 46% fat and 8% protein, and you can eat freely for the remaining 10 days.
All patients continued to take their originally prescribed antidiabetic medications at the start of the study. After 3 months of intervention, 18 (50.0%) of 36 participants in the experimental group and 1 (2.8%) of 36 participants in the control group stopped using antidiabetic drugs under the supervision of doctors. Additionally, 13 of 19 (68.4%) participants in the experimental group and 1 of 35 (2.8%) participants in the control group reduced their diabetes medication intake. The average number of medications taken in the intervention group was significantly lower than in the control group.
After completing the 3-month intervention and 3-month follow-up, 17 (47.2%) of the 36 participants in the experimental group achieved diabetes remission, the average fasting blood sugar in this group dropped to 6.3, and the average weight loss was 5.93 kg. The average BMI reduction was 2.41, while only 1 (2.8%) of the 36 individuals in the control group achieved remission; on the other hand, the average fasting blood sugar in the control group was 7.66, the average weight decreased by 0.27 kg, and the BMI decreased by 0.18.
After 12 months of follow-up, 16 out of 36 subjects (44.4%) in the experimental group achieved diabetes remission, and the glycated hemoglobin level reached 6.33%. The cost of medication in the experimental group was 77.22% lower than that in the control group. The results of the study showed that almost half of the diabetic participants achieved remission through CMNT therapy.
Follow-up for 5 years or more is ongoing to explore the stability and efficacy of CMNT therapy, as well as any complications, the team said. Since the research process was carried out under real-life conditions by trained health nurses, rather than the research team’s own personnel, this makes fasting therapy more feasible to help diabetes care, and it is expected that it will bring benefits to diabetes care in the future. new breakthrough.